San Diego Padres vs Cincinnati Reds – September 1, 2026

The Padres defeated the Reds 5-0 in the series opener and look to extend their advantage in tonight's matchup at Great American Ball Park, with first pitch at 6:40pm ET. Reds starter Randy Vasquez has pitched well in his last four starts, allowing four runs over 23 innings, while Padres starter Nick Lodolo has struggled since returning from injury, giving up 14 runs in 16.1 innings across four appearances. Left-handed hitters have had particular success against Lodolo this season, batting .347 with a .520 slugging percentage, while right-handed batters have struggled against Vasquez with a .217 average. Reds slugger Eugenio Suarez will miss the next two games to take his U.S. naturalization test.

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